Key result
Both 5-HT1-like and 5-HT2 receptors mediate contraction of human epicardial coronary arteries, with 5-HT1-like receptor effects preserved in patients with ischaemic heart disease.
Both 5-HT1-like and 5-HT2 receptors mediate human coronary artery contraction, with 5-HT1-like responses preserved in ischaemic heart disease, highlighting their potential role in coronary vasospasm.
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Characterizes 5-HT receptors in human coronaries; leaves open clinical role in vasospasm and therapeutic targeting.
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Chester et al. (1990) studied Ischaemic heart disease (n=21). 5-hydroxytryptamine (5-HT) and selective receptor agonists/antagonists vs. Normal vessels (without ischaemic heart disease) was evaluated on Vascular contraction and vasorelaxation. Both 5-HT1-like and 5-HT2 receptors mediate contraction of human epicardial coronary arteries, with 5-HT1-like receptor effects preserved in patients with ischaemic heart disease.
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