Key result
5-HT constricts human coronary arteries via 5-HT1 receptors, but engages 5-HT1 and 5-HT2 in saphenous veins.
Why the study?
The receptor subtypes mediating contractions to 5-hydroxytryptamine in human coronary artery and saphenous vein were not fully characterized.
The 5-HT1 receptor is the predominant subtype mediating serotonin-induced contractions in human coronary arteries, whereas both 5-HT1 and 5-HT2 receptors mediate contractions in human saphenous veins.
Should not yet alter clinical vascular management; hypothesis-generating for differential 5-HT receptor roles in human arteries versus veins.
Isometric contractions were obtained to 5-hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5-HT2 receptor antagonist ketanserin, both 5-HT1 and 5-HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5-HT1 receptor.
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Borton et al. (1990) studied this question. 5-hydroxytryptamine-induced contractions are mediated by both 5-HT1 and 5-HT2 receptors in human saphenous veins, but predominantly by 5-HT1 receptors in human coronary arteries.
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