Population
Human epicardial coronary artery rings from explant hearts of patients undergoing heart transplant and…
Comparison
5-HT receptor agonists in the presence of… vs 5-HT receptor agonists alone (without U46619)
Design
Preclinical
Authors
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May warrant caution with triptans during thromboxane activation; leaves open clinical translation to coronary events.
The study demonstrates that thromboxane A2 receptor activation synergistically enhances the contractile response of human coronary arteries to sumatriptan and 5-HT.
Cocks et al. (1993) studied this question.
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