Various agonists can uncover 5-HT1-like receptors in rabbit iliac arteries, amplifying the contractile response to sumatriptan.
Agonist priming may enhance triptan vasoconstriction in vessels; hypothesis-generating for 5-HT1 pharmacology and leaves clinical translation open.
Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2 alpha (PGF2 alpha), angiotensin II (AII), histamine, norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1-like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.
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Yıldız et al. (1995) studied this question.
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