Population
Smooth-muscle strips of small arterial blood vessels of dog and rabbit skin and mesentery
Design
Preclinical
Authors
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Species-specific vasodilator responses in animal vessels caution against clinical extrapolation; leaves open human applicability and requires targeted validation studies.
Vasodilating agents exhibit species- and region-specific responses on vascular smooth muscle in vitro, highlighting the need to account for these variations in preclinical drug testing.
Winkelmann et al. (1969) studied this question.
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