What question did this study set out to answer?

To evaluate and compare cholinergic receptor-mediated vascular responses to acetylcholine and methacholine in the arteriolar and venous beds of the human forearm.

January 1, 1995Blood Pressure

Cholinergic Receptor-Mediated Responses in the Arteriolar and Venous Vascular Beds of the Human Forearm

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Why the study?

Does acetylcholine and methacholine improve vasodilation in the arteriolar and venous vascular beds in healthy volunteers?

Population

Healthy volunteers

Comparison

Acetylcholine (ACh) and methacholine (MCh) vs Sodium nitroprusside as an…

Design

Other

Authors

MKMichiel J. B. KemmeElectrophysiology TBTobias A. BruningMaasstad Ziekenhuis PCPeter C. ChangIntel (United States)

Discussion

Member takes

Implication

Cholinergic dilation appears attenuated in human veins; leaves open differential mechanisms across vascular beds.

Key Points

To evaluate and compare cholinergic receptor-mediated vascular responses to acetylcholine and methacholine in the arteriolar and venous beds of the human forearm.
Simultaneously measured arterial and venous responses in healthy volunteers using venous occlusion plethysmography after vascular preconstriction with methoxamine.
Administered acetylcholine, methacholine, sodium nitroprusside (endothelium-independent control), and atropine (muscarinic receptor antagonist).
Arteries and veins both relaxed in response to agonists, but overall dilator responses to acetylcholine, methacholine, and sodium nitroprusside were weaker in the venous bed.
Acetylcholine failed to produce significant vasodilation in forearm veins due to susceptibility to cholinesterase degradation.
Methacholine-induced vasodilation was blocked by atropine and produced significantly weaker relaxation in veins than sodium nitroprusside (p < 0.05), whereas arterial responses to both agents did not differ significantly on a molar basis.

Structured PICO

Does acetylcholine and methacholine improve vasodilation in the arteriolar and venous vascular beds in healthy volunteers?

Population

Healthy volunteers

Intervention

Acetylcholine (ACh) and methacholine (MCh)

Comparator

Sodium nitroprusside (SNP) as an endothelium-independent control agent

Outcome

Vasodilator responses in arterial and venous vasculature measured by venous occlusion plethysmographysurrogate

Cholinergic agonists exhibit weaker relaxant effects in the venous vascular bed compared to the arterial bed in the human forearm.

Cite This Study

Kemme et al. (1995) studied this question.

synapsesocial.com/papers/6a9761d8824c98cfb78bd66e https://doi.org/10.3109/08037059509077610

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Cholinergic Receptor-Mediated Responses in the Arteriolar and Venous Vascular Beds of the Human Forearm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cholinergic Receptor-Mediated Responses in the Arteriolar and Venous Vascular Beds of the Human Forearm

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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