February 1, 1997Clinical Science
Comparison of Forearm Vasodilatation to Substance P and Acetylcholine: Contribution of Nitric Oxide
Why the study?
Does substance P induce greater nitric oxide-mediated forearm vasodilatation compared to acetylcholine in healthy men?
Population
8 healthy men
Comparison
Incremental challenges of acetylcholine and… vs Saline infusion
Design
Other
Authors
Discussion
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Member takes
Implication
Substance P may be a more NO-specific endothelial probe than acetylcholine in research; leaves open validation and clinical utility.
Structured PICO
Does substance P induce greater nitric oxide-mediated forearm vasodilatation compared to acetylcholine in healthy men?
P
Population
8 healthy men
I
Intervention
Incremental challenges of acetylcholine and substance P administered via the brachial artery in the presence of the nitric oxide synthase inhibitor NG-monomethyl-L-arginine or the control vasoconstrictor noradrenaline
C
Comparator
Saline infusion
O
Outcome
Forearm blood flow measured by venous occlusion plethysmographysurrogate
In healthy men, a greater proportion of forearm vasodilatation to substance P than to acetylcholine is nitric oxide-mediated, suggesting substance P may be a superior pharmacological tool for investigating endothelial function.
Cite This Study
Newby et al. (1997) studied this question.