Why the study?
Does systemic inhibition of prostanoid production or nitric oxide synthesis reduce cutaneous vascular responses to acetylcholine in normal male volunteers?
Population
Normal male volunteers
Comparison
Oral aspirin and intravenous L-NMMA to inhibit… vs Baseline measurements
Design
Other
Authors
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Suggests cutaneous acetylcholine testing probes prostanoid-dependent endothelial function in healthy volunteers; leaves open validation in disease.
Does systemic inhibition of prostanoid production or nitric oxide synthesis reduce cutaneous vascular responses to acetylcholine in normal male volunteers?
Cutaneous vasodilatation to acetylcholine is primarily mediated by a prostanoid-dependent mechanism rather than nitric oxide, highlighting its potential utility in assessing endothelium-dependent prostanoid function.
Khan et al. (1997) studied this question.
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