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June 1, 1998British Journal of Clinical PharmacologyOpen Access

Studies with iontophoretic administration of drugs to human dermal vessels in vivo: cholinergic vasodilatation is mediated by dilator prostanoids rather than nitric oxide

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Why the study?

What mediates cholinergic vasodilatation in human dermal vessels in vivo when assessed by transdermal drug iontophoresis?

Population

Healthy male volunteers

Comparison

Transdermal drug iontophoresis of acetylcholine… vs Brachial artery infusion of noradrenaline and…

Design

Other

Authors

JNJoseph P. NoonCARE CanadaBWBrian R. WalkerNewcastle UniversityMHMalcolm F. HandPfizer (United Kingdom)

Discussion

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Implication

Should not alter aspirin use or NO-targeted therapies; leaves open prostanoid dominance in other vascular beds.

Structured PICO

What mediates cholinergic vasodilatation in human dermal vessels in vivo when assessed by transdermal drug iontophoresis?

P
Population
Healthy male volunteers
I
Intervention
Transdermal drug iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) combined with brachial artery infusion of L-NMMA or intravenous aspirin
C
Comparator
Brachial artery infusion of noradrenaline (as a control for the vasoconstrictor effect of L-NMMA) and baseline measurements
O
Outcome
Vasodilatation measured by laser Doppler fluximetry (flux)surrogate

In human dermal vessels, cholinergic vasodilatation induced by acetylcholine iontophoresis is predominantly mediated by dilator prostanoids rather than nitric oxide.

Cite This Study

Noon et al. (1998) studied this question.

synapsesocial.com/papers/6a710e6b2163a0a01bc53d62https://doi.org/10.1046/j.1365-2125.1998.00718.x
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Also Consider

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  2. 2Renin release selectively stimulated by prostaglandin I2 in isolated rat glomeruli1982 · 46 citations
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  4. 4An investigation into variability in microvascular skin blood flow and the responses to transdermal delivery of acetylcholine at different sites in the forearm and hand1997 · 38 citations