Why the study?
Is endothelium-dependent forearm vasodilation evoked with substance P and acetylcholine impaired in patients with heart failure compared to normal subjects?
Is endothelium-dependent forearm vasodilation evoked with substance P and acetylcholine impaired in patients with heart failure compared to normal subjects?
Endothelium-dependent vasodilation via muscarinic receptors is impaired in heart failure, while vasodilation via substance P receptors is preserved.
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Selective muscarinic endothelial impairment in HF; hypothesis-generating for receptor-specific mechanisms and should not yet change practice.
Hirooka et al. (1992) studied this question.
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