July 1, 1997AJP Heart and Circulatory Physiology

Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves

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Population

Anesthetized hamsters (retractor muscle arterioles and feed arteries)

Comparison

Electrical stimulation of motor nerves or… vs Responses in the absence of specific antagonists

Design

Preclinical

Authors

DWDonald G. WelshWestern University SSSteven S. SegalVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Supports acetylcholine spillover in rodent exercise hyperemia; leaves open translation to human physiology or clinical targeting.

Structured PICO

Population

Anesthetized hamsters (retractor muscle arterioles and feed arteries)

Intervention

Electrical stimulation of motor nerves or microiontophoresis of acetylcholine, in the presence of pharmacological agents (tubocurarine, eserine, atropine)

Comparator

Responses in the absence of specific antagonists (e.g., presence vs. absence of atropine)

Outcome

Vasodilation (changes in diameter of arterioles and feed arteries)surrogate

Acetylcholine spillover from neuromuscular junctions coactivates muscarinic receptors to induce ascending vasodilation, which is integral to functional hyperemia during exercise.

Cite This Study

Welsh et al. (1997) studied this question.

synapsesocial.com/papers/6a721bed6ceb2bbd16e04c6a https://doi.org/10.1152/ajpheart.1997.273.1.h156

View Full Paper

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Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coactivation of resistance vessels and muscle fibers with acetylcholine release from motor nerves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider