March 1, 1962Acta Physiologica Scandinavica

Effects of Different Types of Vasodilator Mechanisms on Vascular Tonus and on Transcapillary Exchange of Diffusible Material in Skeletal Muscle

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Population

Isolated skeletal muscles of dogs and cats perfused with blood at constant flow

Design

Preclinical

Authors

EREugene M. RenkinUniversity of California, Davis SRSune RosellHospital de Sant Pau

Discussion

Member takes

Implication

Supports selective arteriolar effects of cholinergic nerves in animals; leaves open translation to human cardiovascular regulation.

Structured PICO

Population

Isolated skeletal muscles of dogs and cats perfused with blood at constant flow

Intervention

Different types of vasodilator mechanisms (metabolic vasodilatation, inhibition of vasoconstrictor nerves, excitation of cholinergic vasodilator nerves)

Outcome

Vascular tonus (pressure-flow curves) and transcapillary exchange of diffusible material (arteriovenous extraction of rubidium-86)surrogate

Vasodilator nerve activity primarily produces arteriolar dilatation, whereas metabolic vasodilatation or inhibition of vasoconstrictor nerves relaxes smooth muscles in both arterioles and precapillary sphincters.

Cite This Study

Renkin et al. (1962) studied this question.

synapsesocial.com/papers/6a71b73f78a11c550e0bb830 https://doi.org/10.1111/j.1748-1716.1962.tb02349.x

View Full Paper

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Bookmark

Effects of Different Types of Vasodilator Mechanisms on Vascular Tonus and on Transcapillary Exchange of Diffusible Material in Skeletal Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Different Types of Vasodilator Mechanisms on Vascular Tonus and on Transcapillary Exchange of Diffusible Material in Skeletal Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider