Why the study?
Do nitroprusside and nitroglycerin decrease pulmonary vascular resistance in intact-chest dogs under varying levels of vasomotor tone?
Population
Intact-chest dogs
Comparison
Nitroprusside and nitroglycerin vs Control conditions versus elevated pulmonary…
Design
Preclinical
Authors
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Tone-dependent pulmonary vasodilation in dogs warrants model-specific interpretation; leaves open human translation.
Do nitroprusside and nitroglycerin decrease pulmonary vascular resistance in intact-chest dogs under varying levels of vasomotor tone?
Nitroprusside and nitroglycerin act as direct pulmonary vasodilators by dilating intrapulmonary veins and upstream segments, with effects dependent on the existing level of vasomotor tone.
Kadowitz et al. (1981) studied this question.
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