Why the study?
Does nitroprusside alter pulmonary blood volume and pressures in anesthetized dogs?
Population
Closed-chest anesthetized dogs
Comparison
Nitroprusside at various doses across three… vs Decreased venous return produced by partial…
Design
Preclinical
Authors
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Nitroprusside may increase pulmonary blood volume in dogs with maintained left atrial pressure; hypothesis-generating and leaves open human translation.
Does nitroprusside alter pulmonary blood volume and pressures in anesthetized dogs?
Nitroprusside increases pulmonary blood volume when left atrial pressure is maintained, demonstrating its effects on the pulmonary vasculature in a canine model.
Sivak et al. (1979) studied this question.
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