Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog.
Why the study?
What are the hemodynamic effects of intravenous sodium nitroprusside in conscious dogs?
Population
Conscious dogs previously instrumented for measurement of arterial pressure, cardiac output, regional blood…
Comparison
Intravenous sodium nitroprusside 25… vs Baseline (control) before infusion
Design
Preclinical
Follow-up
7 minutes
Authors
Discussion
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Member takes
Implication
Provides foundational hemodynamic data in conscious dogs; human translation requires dedicated clinical trials.
Structured PICO
What are the hemodynamic effects of intravenous sodium nitroprusside in conscious dogs?
P
Population
Conscious dogs previously instrumented for measurement of arterial pressure, cardiac output, regional blood flow distribution, left ventricular (LV) pressure, and internal dimensions
I
Intervention
Intravenous sodium nitroprusside 25 microgram/kg/min for 7 min
C
Comparator
Baseline (control) before infusion
O
Outcome
Hemodynamic effects including arterial pressure, cardiac output, regional blood flow distribution, and left ventricular dimensionssurrogate
Intravenous sodium nitroprusside in conscious dogs substantially reduces LV dimensions while inducing complex, time-dependent changes in peripheral vascular beds due to reflex adjustments.
Cite This Study
Pagani et al. (1978) studied this question.