What does this research mean for the field?

Sodium nitroprusside improves total cardiac performance and the mechanical function of regional ischemic myocardium while increasing regional perfusion and reducing lactate production, thereby alleviating acute ischemia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1975CirculationOpen Access

Hemodynamic and metabolic effects of sodium nitroprusside on the performance and metabolism of regional ischemic myocardium;.

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Why the study?

Does sodium nitroprusside improve cardiac performance and metabolism in a canine model of acute ischemia?

Population

21 open-chest dogs with acute ischemia induced by occlusion of the left anterior descending coronary artery

Comparison

Sodium nitroprusside (5-10 mug/min) vs 7 control dogs with acute ischemia not receiving…

Design

Preclinical

Authors

PLProtásio Lemos da LuzUniversidade de São Paulo JFJames S. ForresterInterventional Cardiology HWH.L. WyattCardiff University

Discussion

Member takes

Implication

Improves ischemic performance in canine myocardium; hypothesis-generating, should not yet change clinical practice.

Structured PICO

Does sodium nitroprusside improve cardiac performance and metabolism in a canine model of acute ischemia?

Population

21 open-chest dogs with acute ischemia induced by occlusion of the left anterior descending coronary artery

Intervention

Sodium nitroprusside (5-10 mug/min)

Comparator

7 control dogs with acute ischemia not receiving nitroprusside

Outcome

Total and regional cardiac performance, energetics, and lactate metabolismsurrogate

Sodium nitroprusside improves mechanical performance and regional perfusion while reducing lactate production in ischemic myocardium in a canine model.

Cite This Study

Luz et al. (1975) studied this question.

synapsesocial.com/papers/6a157949d64fa333899fb5dd https://doi.org/10.1161/01.cir.52.3.400

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Hemodynamic and metabolic effects of sodium nitroprusside on the performance and metabolism of regional ischemic myocardium;.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemodynamic and metabolic effects of sodium nitroprusside on the performance and metabolism of regional ischemic myocardium;.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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