Key result
Global intracoronary infusion of sodium nitroprusside reduced LV peak systolic pressure from 161 to 146 mm Hg (P<0.001) and hastened the onset of LV relaxation from 432 to 419 ms (P<0.01).
Why the study?
Does intracoronary sodium nitroprusside improve left ventricular relaxation and diastolic distensibility in patients without obstructive coronary disease?
Does intracoronary sodium nitroprusside improve left ventricular relaxation and diastolic distensibility in patients without obstructive coronary disease?
Intracoronary infusion of sodium nitroprusside acutely hastens left ventricular relaxation and improves diastolic distensibility in humans, suggesting a direct myocardial effect of nitric oxide.
No takes yet. Share an insight, caveat, or question.
May support direct myocardial NO effects on relaxation; hypothesis-generating and requires randomized trials before any clinical consideration.
Paulus et al. (1994) studied Chest pain without obstructive coronary artery or other cardiac disease (n=13). Sodium nitroprusside vs. Baseline / Right atrial infusion was evaluated on Left ventricular relaxation and diastolic distensibility. Global intracoronary infusion of sodium nitroprusside reduced LV peak systolic pressure from 161 to 146 mm Hg (P<0.001) and hastened the onset of LV relaxation from 432 to 419 ms (P<0.01).
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