Key result
Sodium nitroprusside (0.1-10 microM) induced concentration-dependent increases in coronary flow and faster early left ventricular pressure decline without compromising systolic function.
Why the study?
Does exogenous nitric oxide improve myocardial relaxation in isolated ejecting guinea pig hearts?
Population
isolated ejecting guinea pig hearts at constant filling pressure, afterload, and heart rate
Comparison
exogenous nitric oxide donor, sodium nitroprusside vs nicardipine and hemoglobin
Design
Preclinical
Authors
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NO donor accelerates early LV pressure decline in isolated hearts; hypothesis-generating and leaves open clinical translation.
Does exogenous nitric oxide improve myocardial relaxation in isolated ejecting guinea pig hearts?
Exogenous nitric oxide exerts direct myocardial relaxant effects in the isolated ejecting heart, independent of its vasodilator activity and without compromising systolic function.
Grocott-Mason et al. (1994) studied this question. Sodium nitroprusside vs. Nicardipine was evaluated on Coronary flow and left ventricular pressure decline. Sodium nitroprusside (0.1-10 microM) induced concentration-dependent increases in coronary flow and faster early left ventricular pressure decline without compromising systolic function.
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