Why the study?
Does sodium nitroprusside affect myocardial contractility and haemodynamics in anaesthetized dogs?
Population
6 anaesthetized dogs receiving IPPV with 50% nitrous oxide in oxygen
Design
Preclinical
Authors
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Sodium nitroprusside preserves contractility without raising output in dogs due to preload drop; leaves open translation to human haemodynamics.
Does sodium nitroprusside affect myocardial contractility and haemodynamics in anaesthetized dogs?
In a canine model, sodium nitroprusside preserves myocardial contractility but limits cardiac output increases due to reduced left ventricular filling.
Adams et al. (1974) studied this question.
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