January 1, 1982Japanese Heart JournalOpen Access

Analysis of cardiac actions of Nitroprusside in intact dogs and in isolated atria.

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Population

Cross-circulated dog heart preparation

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital TKTereza M. KOZUShinshu University HWHidehiko WatanabeOregon Health & Science University

Discussion

Member takes

Implication

Caution against attributing direct cardiac effects to nitroprusside; leaves open human validation of indirect catecholamine mechanisms.

Structured PICO

Population

Cross-circulated dog heart preparation (isolated atrial muscle perfused with blood from a pentobarbital anesthetized donor dog)

Intervention

Sodium nitroprusside (intravenous 1-10 micrograms/Kg, >100 micrograms/Kg, and direct intraarterial 10-1,000 micrograms)

Outcome

Cardiac pacemaker activity (chronotropic effects) and contractility (inotropic effects)surrogate

Sodium nitroprusside lacks direct chronotropic and inotropic cardiac effects, with observed cardiac changes mediated by catecholamine release secondary to profound hypotension.

Cite This Study

Chiba et al. (1982) studied this question.

synapsesocial.com/papers/6a77cf9c137c7dcc81be1603 https://doi.org/10.1536/ihj.23.613

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Analysis of cardiac actions of Nitroprusside in intact dogs and in isolated atria.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of cardiac actions of Nitroprusside in intact dogs and in isolated atria.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider