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December 1, 1981CirculationOpen Access

Effects of nitroglycerin and nitroprusside on large and small coronary vessels in conscious dogs.

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Why the study?

Does nitroglycerin compared to nitroprusside differentially affect large and small coronary vessels in conscious dogs?

Population

Conscious dogs

Comparison

Nitroglycerin infusion, 8 microgram/kg/min for 7… vs Nitroprusside infusion, 2.5 microgram/kg/min for…

Design

Preclinical

Follow-up

7 minutes

Authors

PMPilar MachoUniversity of ChileSVStephen F. VatnerHeart Failure & Transplant

Discussion

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Implication

Does not support clinical adoption of differential NTG/NPR use; hypothesis-generating for vessel-size selectivity in humans.

Structured PICO

Does nitroglycerin compared to nitroprusside differentially affect large and small coronary vessels in conscious dogs?

P
Population
Conscious dogs
I
Intervention
Nitroglycerin (NTG) infusion, 8 microgram/kg/min for 7 minutes
C
Comparator
Nitroprusside (NPR) infusion, 2.5 microgram/kg/min for 7 minutes
O
Outcome
Measurements of left circumflex coronary blood flow, coronary diameter, late diastolic coronary resistance (LDCR), and left circumflex coronary internal cross-sectional area (CSA)surrogate

In conscious dogs, nitroglycerin exerts larger and longer-lasting dilation on large coronary arteries, whereas nitroprusside induces greater dilation of small coronary vessels.

Cite This Study

Macho et al. (1981) studied this question.

synapsesocial.com/papers/6a795710bdf697b3de0231fehttps://doi.org/10.1161/01.cir.64.6.1101
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of nitroglycerin on cardiac function and regional blood flow distribution in conscious dogs1978 · 93 citations
  2. 2Hemodynamic effects of intravenous sodium nitroprusside in the conscious dog.1978 · 90 citations
  3. 3Comparison between the effects of nitroprusside and nitroglycerin on ischemic injury during acute myocardial infarction.1976 · 361 citations
  4. 4Comparison of Nitroglycerin-, Nitroprusside-, and Phentolamine-Induced Changes in Coronary Collateral Function in Dogs1977 · 69 citations
  5. 5Effect of Nitroglycerin and Dipyridamole on Regional Coronary Resistance1968 · 264 citations