January 1, 1983Catheterization and Cardiovascular Diagnosis
Comparison of the effects of nitroprusside and nitroglycerin on coronary size
Why the study?
Does nitroprusside produce similar coronary artery dilation compared to nitroglycerin in patients?
Population
12 patients
Comparison
Intravenous infusion of nitroprusside and… vs Baseline measurements before drug administration
Design
Cohort
Authors
Discussion
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Implication
Nitroprusside and nitroglycerin yield comparable coronary dilation at equipotent doses; supports equivalence in this observational cohort but leaves open randomized confirmation.
Key Points
- To compare the vasodilatory effects of nitroprusside and nitroglycerin on various left coronary artery segments at equivalent reductions in aortic pressure.
- Conducted quantitative coronary angiography in 12 patients before and during intravenous nitroprusside infusion and after sublingual nitroglycerin administration.
- Adjusted doses of both medications to achieve comparable target reductions in systemic aortic pressure.
- Both nitroprusside and nitroglycerin induced dilation of measured left coronary artery segments, including large epicardial and smaller intramuscular branches.
- Distal coronary segments exhibited greater dilation than proximal segments after administration of either agent.
- The magnitude of dilation across all measured left coronary artery segments was equivalent between nitroprusside and nitroglycerin at equihypotensive doses, though exact numerical values were not reported.
Structured PICO
Does nitroprusside produce similar coronary artery dilation compared to nitroglycerin in patients?
P
Population
12 patients
I
Intervention
Intravenous infusion of nitroprusside and sublingual nitroglycerin (doses adjusted to achieve reductions in aortic pressure)
C
Comparator
Baseline measurements before drug administration
O
Outcome
Diameters of left coronary artery segments measured by quantitative angiographysurrogate
Both nitroprusside and nitroglycerin are potent dilators of large epicardial and smaller intramuscular coronary artery segments, producing similar degrees of dilation.
Cite This Study
Feldman et al. (1983) studied this question.