August 1, 1981Circulation
Magnitude of dilatation of large and small coronary arteries of nitroglycerin.
Key result
Sublingual nitroglycerin induced coronary artery dilatation, with the greatest magnitude of vasodilatation observed in arteries with the smallest control diameter.
Why the study?
Does sublingual nitroglycerin improve vasodilatation differently based on the baseline size and location of coronary arteries?
Population
34 patients undergoing coronary angiography, including those with and without coronary artery disease.
Comparison
Nitroglycerin 0.4 mg sublingual. vs Baseline measurements.
Design
Cohort
Authors
Discussion
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Implication
Smaller arteries dilate more after nitroglycerin; leaves open whether baseline diameter should guide dosing in ischemia.
Key Points
- The study aims to determine vasodilatory responses of large and small coronary arteries to nitroglycerin.
- 34 patients were assessed using quantitative magnification coronary angiography.
- Nitroglycerin (0.4 mg, sublingual) was administered prior to measurements.
- Both large epicardial and small intramyocardial coronary arteries were evaluated for dilatation.
- CAs with the smallest control diameter showed the greatest magnitude of vasodilation.
- Coronary stenoses exhibited less dilation than nonstenosed segments of similar diameter.
- No significant difference in response when excluding stenotic areas, regardless of coronary artery disease presence.
Structured PICO
Does sublingual nitroglycerin improve vasodilatation differently based on the baseline size and location of coronary arteries?
P
Population
34 patients evaluated for coronary artery vasodilatory responses before and after sublingual nitroglycerin.
I
Intervention
Nitroglycerin 0.4 mg sublingual.
C
Comparator
Baseline measurements (before nitroglycerin administration).
O
Outcome
Vasodilatory responses (magnitude of dilatation) of segments of large epicardial left coronary artery, small intramyocardial coronary arteries (0.3-1.0 mm), coronary stenoses, and coronary arteries filled by collaterals, measured by quantitative magnification coronary angiography.surrogate
The principal determinant of coronary artery vasodilatory response to sublingual nitroglycerin is the baseline size of the artery, with smaller vessels exhibiting greater dilatation.
Cite This Study
Feldman et al. (1981) studied Patients undergoing coronary angiography (n=34). Nitroglycerin vs. Baseline (before nitroglycerin) was evaluated on Magnitude of dilatation of coronary arteries. Sublingual nitroglycerin induced coronary artery dilatation, with the greatest magnitude of vasodilatation observed in arteries with the smallest control diameter.