Key result
The mononitrates SPM-4744 and SPM-5185 produced significantly greater dilation in large (55% and 43%) versus small (18% and 16%) coronary microvessels (p < 0.001).
Population
Large and small porcine coronary microvessels studied in vitro, isolated rat hearts, and isolated segments…
Comparison
Mononitrates SPM-4744 and SPM-5185 vs Nitroglycerin and sodium nitroprusside
Design
Preclinical
Authors
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In vitro coronary selectivity by organic nitrates leaves open in vivo microvascular relevance; clinical translation requires prospective confirmation.
p-value: p=< 0.001
The organic mononitrates SPM-4744 and SPM-5185 demonstrate selectivity for larger coronary microvessels, similar to nitroglycerin, with minimal dilation of vessels <100 microns.
Wang et al. (1996) studied this question. SPM-4744 and SPM-5185 vs. Small coronary microvessels was evaluated on Maximal dilations as a percent of preconstricted tone (p=< 0.001). The mononitrates SPM-4744 and SPM-5185 produced significantly greater dilation in large (55% and 43%) versus small (18% and 16%) coronary microvessels (p < 0.001).
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