February 1, 1990AJP Heart and Circulatory Physiology
Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin
Key result
Nitroglycerin induced 90% relaxation in large porcine coronary microvessels compared to only 20% in small microvessels, indicating diminished biotransformation in smaller resistance vessels.
Population
Porcine coronary microvessels preconstricted with acetylcholine
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for vessel-size effects in humans; does not yet inform clinical nitroglycerin use.
Structured PICO
P
Population
Porcine coronary microvessels (small 60-100 microns, medium 101-190 microns, and large 191-300 microns) preconstricted with acetylcholine
I
Intervention
Nitroglycerin, S-nitrosocysteine, nitric oxide, bradykinin, calcium ionophore A23187, and LY 83583
O
Outcome
Vasorelaxation responsesurrogate
Main Result
Absolute Event Rate: 90% vs 20%
Nitroglycerin-induced vasodilation is diminished in small coronary microvessels compared to larger ones, likely due to reduced biotransformation into active metabolites.
Cite This Study
Sellke et al. (1990) studied Porcine coronary microvessels. Nitroglycerin vs. Different vessel sizes (small vs large) was evaluated on Relaxation response to nitroglycerin. Nitroglycerin induced 90% relaxation in large porcine coronary microvessels compared to only 20% in small microvessels, indicating diminished biotransformation in smaller resistance vessels.