January 1, 1978Japanese Heart JournalOpen Access

Comparative Vasodilator Effects of Nitroprusside, Phentolamine, and Nitroglycerin on Hemo dynamics, Regional Myocardial Function and Epicardial Electrogram in Dogs with Acute Myocardial Ischemia

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Why the study?

Does nitroprusside, phentolamine, or nitroglycerin improve hemodynamics and regional myocardial function in a canine model of acute myocardial ischemia?

Population

Anesthetized open chest dogs with acute myocardial ischemia induced by complete occlusion of the anterior…

Comparison

Nitroprusside, phentolamine, or nitroglycerin. vs Comparative study between the three vasodilator…

Design

Preclinical

Authors

DSDaiji SaitoCity Hospital MUMinoru UedaTohoku University HYHidenori YoshidaKagawa University

Discussion

Member takes

Implication

Hypothesis-generating in canine ischemia; leaves open translation of afterload/preload effects to human acute MI.

Structured PICO

Does nitroprusside, phentolamine, or nitroglycerin improve hemodynamics and regional myocardial function in a canine model of acute myocardial ischemia?

Population

Anesthetized open chest dogs with acute myocardial ischemia induced by complete occlusion of the anterior descending coronary artery (LAD).

Intervention

Nitroprusside (5 microgram/Kg/min drip-infused), phentolamine (100 microgram/Kg/min drip-infused), or nitroglycerin (20 microgram/Kg intravenous bolus).

Comparator

Comparative study between the three vasodilator agents (nitroprusside, phentolamine, and nitroglycerin).

Outcome

Systemic hemodynamics (systemic arterial pressure, total peripheral resistance, left ventricular end-diastolic pressure, cardiac output), regional contraction (paradoxical systolic lengthening), and epicardial ST segment in the border and non-ischemic zones.surrogate

In a canine model of acute myocardial ischemia, nitroprusside and nitroglycerin improve ischemic myocardium through afterload and preload reduction respectively, whereas phentolamine does not significantly improve ischemia.

Cite This Study

Saito et al. (1978) studied this question.

synapsesocial.com/papers/6a77cf9c137c7dcc81be160a https://doi.org/10.1536/ihj.19.926

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Comparative Vasodilator Effects of Nitroprusside, Phentolamine, and Nitroglycerin on Hemo dynamics, Regional Myocardial Function and Epicardial Electrogram in Dogs with Acute Myocardial Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparative Vasodilator Effects of Nitroprusside, Phentolamine, and Nitroglycerin on Hemo dynamics, Regional Myocardial Function and Epicardial Electrogram in Dogs with Acute Myocardial Ischemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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