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August 1, 1977Journal of Clinical InvestigationOpen Access

Comparison of Nitroglycerin-, Nitroprusside-, and Phentolamine-Induced Changes in Coronary Collateral Function in Dogs

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Why the study?

Do nitroglycerin, nitroprusside, and phentolamine alter coronary collateral flow in a canine model of coronary occlusion?

Population

Dogs studied 2-4 weeks after an ameroid constrictor was placed around the left anterior descending coronary…

Comparison

Nitroglycerin, nitroprusside, and phentolamine. vs Comparison between the different drugs and…

Design

Preclinical

Authors

NCNorine L. CapurroAmes Research CenterKKKenneth M. KentBoston UniversitySEStephen E. EpsteinBroad Institute

Discussion

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Implication

Should not guide vasodilator selection in acute ischemia; hypothesis-generating for differential collateral modulation in occlusion models.

Structured PICO

Do nitroglycerin, nitroprusside, and phentolamine alter coronary collateral flow in a canine model of coronary occlusion?

P
Population
Dogs studied 2-4 weeks after an ameroid constrictor was placed around the left anterior descending (LAD) coronary artery.
I
Intervention
Nitroglycerin (0.3-100 mug/min intracoronary, 3-300 mug/min intravenous), nitroprusside (3-100 mug/min intracoronary, 100-300 mug/min intravenous), and phentolamine (1-300 mug/min intravenous).
C
Comparator
Comparison between the different drugs and routes of administration.
O
Outcome
Changes in retrograde flow and peripheral coronary pressure.surrogate

In a canine model, intravenous nitroglycerin is more effective than nitroprusside in augmenting coronary collateral flow, whereas phentolamine impairs it.

Cite This Study

Capurro et al. (1977) studied this question.

synapsesocial.com/papers/6a73f6ff2960bd03ae1ee837https://doi.org/10.1172/jci108777
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of nitroglycerin and nitroglycerin-methoxamine during acute myocardial ischemia in dogs with pre-existing multivessel coronary occlusive disease.1975 · 51 citations
  2. 2Some Determinants of Coronary Collateral Blood Flow in the Open-Chest Dog1959 · 116 citations
  3. 3Effect of Nitroglycerin and Dipyridamole on Regional Coronary Resistance1968 · 264 citations
  4. 4Reversal by Phenylephrine of the Beneficial Effects of Intravenous Nitroglycerin in Patients with Acute Myocardial Infarction1975 · 137 citations
  5. 5Reduction in Severity and Extent of Myocardial Infarction When Nitroglycerin and Methoxamine are Administered during Coronary Occlusion1974 · 103 citations