Why the study?
Does nitroprusside alter vascular resistance and volume, and what is the role of the spleen in these changes in dogs?
Does nitroprusside alter vascular resistance and volume, and what is the role of the spleen in these changes in dogs?
Nitroprusside decreases vascular resistance and increases vascular volume, with the spleen being the major site of volume changes in dogs.
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Spleen accounts for most nitroprusside-driven volume expansion in dogs; leaves open relevance to human vascular capacitance.
Rubin et al. (1979) studied this question.
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