Key result
Embolization with autologous blood clot to produce marked pulmonary hypertension depressed the mean slope of the PAP-LAP relationship from 0.78 to 0.16 (P<0.001).
Population
13 dogs subjected to autologous blood clot embolization to produce pulmonary hypertension.
Comparison
Autologous blood clot embolization to produce… vs Pre-embolization baseline and comparison between…
Design
Preclinical
Authors
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Alerts to vascular waterfall in severe canine PH; leaves open human hemodynamic relevance.
Absolute Event Rate: 0.16% vs 0.78%
p-value: p=<0.001
In a canine model of embolic pulmonary hypertension, upstream transmission of left atrial pressure is inversely related to the pressure intercept, creating an effective vascular waterfall in marked pulmonary hypertension.
Hasinoff et al. (1990) studied Canine embolic pulmonary hypertension (n=13). Embolization with autologous blood clot vs. Before embolization was evaluated on Slope of the PAP-LAP relationship (p=<0.001). Embolization with autologous blood clot to produce marked pulmonary hypertension depressed the mean slope of the PAP-LAP relationship from 0.78 to 0.16 (P<0.001).
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