Key result
Varying pulmonary capillary wedge pressure with cardiac output resulted in a significantly greater slope of the pulmonary artery pressure-cardiac output plot compared to when PCWP was constant.
Why the study?
Does altering pulmonary capillary wedge pressure affect the slope and extrapolated pressure intercept of the pulmonary artery pressure-cardiac output relationship in anesthetized dogs?
Population
10 intact anesthetized dogs (Group 1: n=6 entirely in West zone 3; Group 2: n=4 with mixed West zone 2-3)
Comparison
Alteration of pulmonary capillary wedge pressure… vs Comparisons between the four PCWP conditions
Design
Preclinical
Authors
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Caution against varying PCWP in pulmonary pressure-flow plots; leaves open accurate resistance assessment without constant PCWP in animal models.
Does altering pulmonary capillary wedge pressure affect the slope and extrapolated pressure intercept of the pulmonary artery pressure-cardiac output relationship in anesthetized dogs?
When PCWP varies during the generation of a pulmonary artery pressure-flow plot, the resulting slope and intercept do not accurately represent the incremental resistance and outflow pressure of the pulmonary vasculature.
Ducas et al. (1988) studied this question. Changes in pulmonary capillary wedge pressure (PCWP) vs. Fixed low PCWP, fixed high PCWP, and variable PCWP was evaluated on Slope (incremental resistance) and extrapolated pressure intercept (PI) of the mean pulmonary artery pressure (PAP)-cardiac output (CO) relationship. Varying pulmonary capillary wedge pressure with cardiac output resulted in a significantly greater slope of the pulmonary artery pressure-cardiac output plot compared to when PCWP was constant.
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