Why the study?
Does ketanserin improve cardiopulmonary hemodynamics in a canine model of experimental pulmonary embolism?
Population
14 dogs with experimental pulmonary embolism induced by IV injection of autologous clot (0.75 g/kg).
Comparison
Ketanserin 0.15 mg/kg bolus infusion… vs Untreated embolized control dogs.
Design
Preclinical, Randomly assigned to the treatment group
Follow-up
4 hours
Authors
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Supports 5-HT inhibition in canine PE models; leaves open translation to human therapy.
Does ketanserin improve cardiopulmonary hemodynamics in a canine model of experimental pulmonary embolism?
Inhibition of 5-HT with ketanserin significantly improves cardiopulmonary hemodynamics and vascular recruitment in a canine model of pulmonary embolism.
HUVAL et al. (1983) studied this question.
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