Key result
B.A.S. inhibits nonembolized lung edema in ~88% of dogs, suggesting antiadrenergic rather than antiserotonin mechanisms.
Why the study?
Does the administration of antiserotonins inhibit pulmonary edema in dogs with starch-induced pulmonary embolization?
Population
Pentobarbitalized dogs with localized pulmonary infarction produced by injecting a starch suspension into…
Design
Preclinical
Authors
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Antiserotonin agents show limited efficacy in canine post-embolic edema; leaves open sympathetic reflex mediation for human studies.
Does the administration of antiserotonins inhibit pulmonary edema in dogs with starch-induced pulmonary embolization?
The study suggests that pulmonary edema following starch emboli is mediated by sympathetic nervous system reflexes releasing catecholamines and histamine, rather than serotonin.
Kabins et al. (1960) studied Pulmonary embolization and lung edema. Antiserotonins (B.A.S., DHE, BOL) was evaluated on Inhibition of edema in nonembolized lung lobes. Edema in nonembolized lung lobes was inhibited in 88% of dogs treated with B.A.S., 45% with DHE, and 12% with BOL, suggesting antiadrenergic rather than antiserotonin mechanisms.
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