November 30, 1957American Journal of Physiology-Legacy Content

Hemodynamic Alterations Following Miliary Pulmonary Embolization in Relation to the Pathogenesis of the Consequent Diffuse Edema

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Population

Animal model of miliary pulmonary embolization

Comparison

Unilobar miliary pulmonary embolization with… vs Right ventricle injection of starch

Design

Preclinical

Follow-up

during the course of the procedure

Authors

DSDonald H. SingerNorthwestern University PSPAUL W. SALTZMANCardiovascular Institute of the South CRCarmen Rivera-EstradaMercy Hospital and Medical Center

Discussion

Member takes

Implication

Altered permeability may drive embolization-related edema in models; leaves open human relevance and therapeutic targeting.

Structured PICO

Population

Animal model of miliary pulmonary embolization

Intervention

Unilobar miliary pulmonary embolization with starch (with or without drug pretreatment)

Comparator

Right ventricle injection of starch (disseminated distribution)

Outcome

Hemodynamic alterations (left atrial pressure, pulmonary arterial wedge pressure, pulmonary venous pressure) and edema formationsurrogate

Diffuse lung edema following miliary pulmonary embolization is likely driven by altered capillary permeability rather than capillary hydrostatic pressure changes.

Cite This Study

Singer et al. (1957) studied this question.

synapsesocial.com/papers/6a82b2c17a209f4aae23b75b https://doi.org/10.1152/ajplegacy.1957.191.3.437

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Hemodynamic Alterations Following Miliary Pulmonary Embolization in Relation to the Pathogenesis of the Consequent Diffuse Edema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemodynamic Alterations Following Miliary Pulmonary Embolization in Relation to the Pathogenesis of the Consequent Diffuse Edema

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider