June 1, 1983Journal of Applied Physiology
Granulocytes mediate the increase in pulmonary vascular permeability after thrombin embolism
Key result
Reduction of the granulocyte count with hydroxyurea prevented the increase in pulmonary vascular permeability after thrombin-induced pulmonary embolization in sheep.
Why the study?
Do granulocytes mediate the increase in pulmonary vascular permeability after thrombin-induced pulmonary embolism in sheep?
Population
Anesthetized artificially ventilated sheep prepared with lung lymph fistulas
Comparison
Granulocyte depletion with hydroxyurea prior to… vs Thrombin-induced pulmonary embolization alone or…
Design
Preclinical
Follow-up
2 hours after thrombin
Authors
Discussion
Loading...
Member takes
Implication
Granulocyte depletion attenuates permeability in ovine embolism; hypothesis-generating for human PE and requires clinical validation.
Structured PICO
Do granulocytes mediate the increase in pulmonary vascular permeability after thrombin-induced pulmonary embolism in sheep?
P
Population
Anesthetized artificially ventilated sheep prepared with lung lymph fistulas subjected to thrombin-induced pulmonary embolization.
I
Intervention
Granulocyte depletion with hydroxyurea prior to thrombin-induced pulmonary embolization
C
Comparator
Thrombin-induced pulmonary embolization alone (control) or with platelet depletion (antiplatelet serum)
O
Outcome
Pulmonary vascular permeability to proteins (assessed via pulmonary lymph flow [Qlym] and lymph-to-plasma protein ratio [L/P])surrogate
Granulocytes, rather than platelets, are the primary cellular mediators of increased pulmonary vascular permeability following thrombin-induced microembolism.
Cite This Study
Tahamont et al. (1983) studied Pulmonary embolization. Granulocyte depletion with hydroxyurea vs. Control and platelet-depleted groups was evaluated on Pulmonary vascular permeability (pulmonary lymph flow and lymph-to-plasma protein ratio). Reduction of the granulocyte count with hydroxyurea prevented the increase in pulmonary vascular permeability after thrombin-induced pulmonary embolization in sheep.