Why the study?
Does platelet depletion prevent increased lung vascular permeability after microemboli in sheep?
Population
16 anesthetized sheep
Comparison
Platelet depletion using antiplatelet serum… vs Untreated sheep receiving glass bead microemboli
Design
Preclinical
Authors
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Platelet depletion does not prevent emboli-induced lung lymph flow increases in sheep; leaves open platelets' role in human pulmonary microvascular injury.
Does platelet depletion prevent increased lung vascular permeability after microemboli in sheep?
In a sheep model, platelets augment pulmonary hypertension following microemboli but are not essential for the resulting microvascular injury.
Binder et al. (1980) studied this question.
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