Key result
Neither large doses of heparin nor fibrinogen depletion with ancrod prevented increased lung vascular permeability after glass bead microembolization in sheep.
Why the study?
Does heparin or fibrinogen depletion prevent increased lung vascular permeability after microemboli in sheep?
Population
20 anesthetized ventilated sheep
Design
Preclinical
Authors
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Fibrin-independent mechanisms may drive microembolic lung injury in sheep; leaves open alternative pathways and human translational relevance.
Does heparin or fibrinogen depletion prevent increased lung vascular permeability after microemboli in sheep?
Fibrin deposition and degradation are not essential to microembolic lung vascular injury in a sheep model.
Binder et al. (1979) studied microembolic lung vascular injury (n=20). Heparin or fibrinogen depletion (ancrod) was evaluated on lung vascular permeability. Neither large doses of heparin nor fibrinogen depletion with ancrod prevented increased lung vascular permeability after glass bead microembolization in sheep.
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