Why the study?
Does acute hypoproteinemia increase fluid flux across the pulmonary and soft tissue microcirculation in unanesthetized sheep?
Population
Unanesthetized sheep
Comparison
Acute hypoproteinemia with constant vascular… vs Baseline values prior to protein depletion and…
Design
Preclinical
Follow-up
Up to 72 hours
Authors
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Acute hypoproteinemia may increase soft tissue fluid flux; leaves open interstitial matrix mechanisms in human critical illness.
Does acute hypoproteinemia increase fluid flux across the pulmonary and soft tissue microcirculation in unanesthetized sheep?
Acute hypoproteinemia causes a prolonged increase in soft tissue fluid flux unrelated to oncotic pressure changes, suggesting alterations in the interstitial matrix that are prevented in the lung.
Harms et al. (1981) studied this question.
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