Key result
Elevation of myocardial venous pressure in dogs decreased lymph protein concentration and colloid osmotic pressure, limiting the effectiveness of protein washdown as a defense against myocardial edema.
Why the study?
Does elevation of myocardial venous pressure alter the distribution of interstitial proteins and affect colloid osmotic pressure in a canine model?
Population
Dogs instrumented with coronary sinus balloon-tipped catheters and myocardial lymphatic cannulas
Design
Preclinical
Authors
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Suggests limited protein washdown defense in canine edema; leaves open relevance to human myocardial edema.
Does elevation of myocardial venous pressure alter the distribution of interstitial proteins and affect colloid osmotic pressure in a canine model?
Protein washdown alters the distribution of interstitial fluid protein species, which decreases its effect on interstitial fluid colloid osmotic pressure and limits its role as a defense against myocardial edema.
Stewart et al. (2000) studied Myocardial edema. Elevation of myocardial venous pressure by balloon inflation was evaluated on Colloid osmotic pressure (COP) of lymph and protein concentration. Elevation of myocardial venous pressure in dogs decreased lymph protein concentration and colloid osmotic pressure, limiting the effectiveness of protein washdown as a defense against myocardial edema.
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