Key result
Acute arterial hypertension increased myocardial microvascular fluid filtration, but combined with coronary sinus pressure elevation, it was insufficient to produce filtration independence.
Population
9 mechanically ventilated dogs
Comparison
Acute arterial hypertension induced by central… vs Baseline/control state prior to pressure…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether combined pressures achieve myocardial filtration independence in vivo.
Acute arterial hypertension increases myocardial microvascular fluid filtration in a canine model, though combining it with coronary sinus pressure elevation is insufficient to determine the myocardial osmotic reflection coefficient.
Mehlhorn et al. (1996) studied Acute arterial hypertension (n=9). Acute arterial hypertension and coronary sinus pressure elevation vs. Baseline/control was evaluated on Myocardial lymph flow rate, lymph driving pressure, and lymph-to-plasma concentration ratios for total protein and albumin. Acute arterial hypertension increased myocardial microvascular fluid filtration, but combined with coronary sinus pressure elevation, it was insufficient to produce filtration independence.
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