What question did this study set out to answer?

To determine whether hypertension and left ventricular hypertrophy magnify transmural differences in coronary microvascular pressures.

July 1, 1992Circulation ResearchOpen Access

Effect of hypertension and hypertrophy on coronary microvascular pressure.

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Population

Isolated lidocaine-arrested hearts from normotensive (n=19) and hypertensive (one clip, one kidney, n=10) dogs

Comparison

Hypertension and left ventricular hypertrophy vs Normotensive controls

Design

Preclinical

Authors

MFMikio FujiiInternational University of Health and Welfare DND W NunoUniversity of Iowa KLKathryn G. LampingUniversity of Iowa

Discussion

Member takes

Implication

May link hypertrophy to subendocardial ischemia vulnerability; leaves open human relevance.

Key Points

To determine whether hypertension and left ventricular hypertrophy magnify transmural differences in coronary microvascular pressures.
Evaluated isolated lidocaine-arrested hearts undergoing adenosine-induced maximal vasodilation in normotensive (n = 19) and one-clip, one-kidney hypertensive (n = 10) dogs.
Measured microvascular pressures in epicardial and endocardial arterioles across left main coronary perfusion pressures from 60 to 100 mm Hg.
Endocardial arteriolar pressures were significantly lower than epicardial arteriolar pressures across all perfusion pressures (60 to 100 mm Hg) in both normotensive and hypertensive groups (p < 0.05).
Epicardial arteriolar pressure percentages relative to left main perfusion pressure did not differ between normotensive and hypertensive hearts across all perfusion pressures.
Endocardial arteriolar pressures were significantly lower in hypertensive hearts than in control hearts at 90 mm Hg (41 ± 4 vs 50 ± 2 mm Hg, p < 0.05) and 100 mm Hg (40 ± 4 vs 50 ± 3 mm Hg, p < 0.05) of perfusion pressure.

Structured PICO

Population

Isolated lidocaine-arrested hearts from normotensive (n=19) and hypertensive (one clip, one kidney, n=10) dogs

Intervention

Hypertension and left ventricular hypertrophy (one clip, one kidney model)

Comparator

Normotensive controls

Outcome

Epicardial and endocardial microvascular pressures during adenosine vasodilation at various left main coronary perfusion pressuressurrogate

Hearts with myocardial hypertrophy secondary to hypertension exhibit greater transmural resistance to microvascular perfusion, which may contribute to vulnerability to subendocardial ischemia.

Cite This Study

Fujii et al. (1992) studied this question.

synapsesocial.com/papers/6a8c38d80ca85c7e33df32a4 https://doi.org/10.1161/01.res.71.1.120

Topics

Hypertension management

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Effect of hypertension and hypertrophy on coronary microvascular pressure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of hypertension and hypertrophy on coronary microvascular pressure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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