The effect of hypertension and left ventricular hypertrophy on the lower range of coronary autoregulation.
Why the study?
Does hypertension and left ventricular hypertrophy impair coronary autoregulation at lower perfusion pressures in a canine model?
Population
23 dogs: 12 with hypertension and left ventricular hypertrophy and 11 normal dogs.
Comparison
Reduction of circumflex coronary pressure to… vs Normal dogs undergoing the same pressure…
Design
Preclinical
Authors
Discussion
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Implication
May increase subendocardial ischemia risk during hypotension in hypertensive LVH; hypothesis-generating in dogs, requires human studies.
Structured PICO
Does hypertension and left ventricular hypertrophy impair coronary autoregulation at lower perfusion pressures in a canine model?
P
Population
23 dogs: 12 with hypertension and left ventricular hypertrophy (one-kidney, one-clip model) and 11 normal dogs.
I
Intervention
Reduction of circumflex coronary pressure to 100, 75, and 40 mm Hg using a hydraulic occluder.
C
Comparator
Normal dogs undergoing the same pressure reduction protocol.
O
Outcome
Myocardial perfusion measured with radioactive microspheres and autoregulatory gain values.surrogate
In a canine model, hypertension and left ventricular hypertrophy are associated with impaired coronary autoregulation, particularly in the subendocardium at lower perfusion pressures.
Cite This Study
Harrison et al. (1988) studied this question.