What question did this study set out to answer?

April 1, 1996HeartOpen Access

Coronary haemodynamics in left ventricular hypertrophy.

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Why the study?

Does hypertensive left ventricular hypertrophy alter coronary blood flow and autoregulation during acute hypotension compared to patients with atypical chest pain?

Population

15 patients, all with angiographically normal epicardial vessels.

Comparison

Measurement of coronary blood flow velocity… vs Patients with atypical chest pain compared to…

Design

Cross-sectional

Authors

DWDavid WallbridgeRoyal Shrewsbury Hospital SCSM CobbeGlasgow Royal Infirmary

Discussion

Member takes

Implication

Reduced coronary flow per LV mass in hypertensive LVH without autoregulatory shift; hypothesis-generating for ischemia risk during hypotension.

Key Points

This research aims to assess coronary blood flow velocity and flow reserve during acute hypotension in left ventricular hypertrophy patients.
Measured left coronary blood flow velocity using Doppler catheter during acute hypotension.
Quantitative coronary angiography was performed manually to derive absolute blood flow.
Patients included those with atypical chest pain and hypertensive left ventricular hypertrophy with normal epicardial vessels.
Coronary blood flow velocity remained constant across various physiological blood pressures.
During maximal hyperaemia, there was a steep dependence on diastolic blood pressure.
The hypertensive group exhibited reduced absolute coronary blood flow at rest and during vasodilatation, indicating inadequate blood supply.

Structured PICO

Does hypertensive left ventricular hypertrophy alter coronary blood flow and autoregulation during acute hypotension compared to patients with atypical chest pain?

Population

15 patients (8 with atypical chest pain and 7 with hypertensive left ventricular hypertrophy), all with angiographically normal epicardial vessels.

Intervention

Measurement of coronary blood flow velocity using a Doppler tipped catheter during acute hypotension with sodium nitroprusside at rest and during maximal hyperemia with intracoronary adenosine.

Comparator

Patients with atypical chest pain (control group) compared to patients with hypertensive left ventricular hypertrophy.

Outcome

Coronary blood flow (velocity) and flow reserve during acute hypotension.surrogate

Patients with hypertensive left ventricular hypertrophy have reduced coronary blood flow per unit of LV mass, but their autoregulatory range is not shifted upwards during acute hypotension.

Cite This Study

Wallbridge et al. (1996) studied this question.

synapsesocial.com/papers/6a7055c835aa2c282ce1a46c https://doi.org/10.1136/hrt.75.4.369

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Implication

Reduced coronary flow per LV mass in hypertensive LVH without autoregulatory shift; hypothesis-generating for ischemia risk during hypotension.

Coronary haemodynamics in left ventricular hypertrophy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary haemodynamics in left ventricular hypertrophy.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider