Why the study?
Does hypertension impair coronary flow reserve in humans, and what are the mechanisms?
Population
50 subjects including 17 healthy controls and 33 hypertensive subjects
Comparison
Pharmacological vasodilation with dipyridamole vs Healthy control subjects
Design
Cross-sectional
Authors
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Impaired coronary reserve in early hypertension supports mechanistic studies; leaves open prognostic value and therapeutic implications.
Does hypertension impair coronary flow reserve in humans, and what are the mechanisms?
Coronary flow reserve is impaired in hypertensive patients even before the development of left ventricular hypertrophy, driven by both increased resting flow and impaired maximal vasodilation.
Kozàkovà et al. (1997) studied this question.
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