Key result
Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.
Why the study?
Does myocardial interstitial edema compromise cardiac function and potentiate interstitial fibrosis in canine models?
Population
Dogs divided into three groups: 1) control, 2) chronic pulmonary hypertensive with right heart failure, and…
Comparison
Acute elevation of coronary venous pressure and… vs Control dogs and baseline measurements
Design
Preclinical
Authors
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Myocardial edema may impair output in dogs; hypothesis-generating for its role in human HF progression and fibrosis.
Does myocardial interstitial edema compromise cardiac function and potentiate interstitial fibrosis in canine models?
Absolute Event Rate: 3.45% vs 2.9%
Myocardial interstitial edema compromises cardiac function and is associated with increased interstitial fibrosis in canine models of hypertension and heart failure.
Laine et al. (1991) studied Myocardial interstitial edema. Myocardial interstitial edema (acute and chronic) vs. Control was evaluated on Extravascular fluid (EVF) ratio. Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.
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