Key result
Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.
Why the study?
Does myocardial interstitial edema compromise cardiac function and potentiate interstitial fibrosis in canine models?
Does myocardial interstitial edema compromise cardiac function and potentiate interstitial fibrosis in canine models?
Absolute Event Rate: 3.45% vs 2.9%
Myocardial interstitial edema compromises cardiac function and is associated with increased interstitial fibrosis in canine models of hypertension and heart failure.
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Myocardial edema may impair output in dogs; hypothesis-generating for its role in human HF progression and fibrosis.
Laine et al. (1991) studied Myocardial interstitial edema. Myocardial interstitial edema (acute and chronic) vs. Control was evaluated on Extravascular fluid (EVF) ratio. Myocardial interstitial edema (EVF of 3.5 vs 2.9 in controls) produced an approximately 30% reduction in the heart's ability to maintain cardiac output in dogs.
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