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October 1, 1999Critical Care Medicine

Factors associated with increased extravascular lung water in cardiac tamponade and myocardial ischemia

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Why the study?

What factors are associated with increased extravascular lung water in cardiac tamponade versus myocardial ischemia in a canine model?

Population

24 anesthetized dogs

Comparison

Cardiac tamponade model and myocardial ischemia… vs Baseline control levels and post-intervention…

Design

Preclinical

Authors

SKShuji KitashiroTonan HospitalTSTetsuro SugiuraKansai Medical UniversityTTTeruhiro TamuraKansai Medical University

Discussion

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Implication

Suggests PCWP may not reflect lung water after reperfusion; leaves open translation of these mechanisms to human cardiac conditions.

Structured PICO

What factors are associated with increased extravascular lung water in cardiac tamponade versus myocardial ischemia in a canine model?

P
Population
24 anesthetized dogs (14 for extravascular lung water and hemodynamics [7 in tamponade model, 7 in myocardial ischemia model]; 10 for colloid osmotic pressure and blood gas analysis)
I
Intervention
Cardiac tamponade model and myocardial ischemia model
C
Comparator
Baseline control levels and post-intervention periods (release of tamponade or reperfusion)
O
Outcome
Extravascular lung water (EVLW) and hemodynamic indices (mean right atrial pressure, pulmonary capillary wedge pressure)surrogate

Hydrostatic pressure is a primary determinant of pulmonary edema in cardiac tamponade, but not during reperfusion after myocardial ischemia, suggesting different mechanisms of fluid accumulation.

Cite This Study

Kitashiro et al. (1999) studied this question.

synapsesocial.com/papers/6a98bb9d69beaaaa83aef41bhttps://doi.org/10.1097/00003246-199910000-00027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased extravascular lung water in patients with low pulmonary artery occlusion pressure after acute myocardial infarction1991 · 27 citations
  2. 2Pericardial effusion causes interstitial pulmonary edema in dogs.1987 · 13 citations
  3. 3Extravascular water content of heart and lungs after acute myocardial ischemia1978 · 29 citations
  4. 4Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.1982 · 26 citations
  5. 5The relative merits of pulsus paradoxus and right ventricular diastolic collapse in the early detection of cardiac tamponade: an experimental echocardiographic study.1985 · 47 citations