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July 1, 1978Journal of Applied Physiology

Extravascular water content of heart and lungs after acute myocardial ischemia

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Population

Anesthetized dogs

Comparison

Circumflex artery ligation, increased left… vs Sham operation

Design

Preclinical

Follow-up

4 hours

Authors

MGM. H. GeeThomas Jefferson UniversityPGPatricia A. GwirtzUniversity of North TexasJSJ. A. SpathUniversitätsklinikum Würzburg

Discussion

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Implication

Ischemia may increase cardiac/pulmonary vascular permeability independent of hemodynamics; leaves open clinical translation from this animal model.

Structured PICO

P
Population
Anesthetized dogs
I
Intervention
Circumflex artery ligation, increased left atrial pressure (Pla), or increased Pla and circumflex artery ligation
C
Comparator
Sham operation
O
Outcome
Extravascular water content of hearts and lungs at 4 hourssurrogate

Acute myocardial ischemia contributes to an increase in vascular permeability in the heart and lungs, independent of hemodynamic mechanisms.

Cite This Study

Gee et al. (1978) studied this question.

synapsesocial.com/papers/6a7e3c301fdb7ee677c768a3https://doi.org/10.1152/jappl.1978.45.1.102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary edema formation with myocardial infarction and left atrial hypertension: intravascular and extravascular pulmonary fluid volumes.1983 · 21 citations
  2. 2Pulmonary and coronary endothelial effects of acute myocardial ischemia in dogs1982 · 9 citations
  3. 3Factors associated with increased extravascular lung water in cardiac tamponade and myocardial ischemia1999 · 8 citations
  4. 4Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.1982 · 26 citations
  5. 5Distensibility and Water Content of Heart Muscle Before and After Injury1960 · 41 citations