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February 1, 1982Circulation ResearchOpen Access

Non-hydrostatic pulmonary edema after coronary artery ligation in dogs. Protective effect of indomethacin.

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Why the study?

Does indomethacin infusion prevent non-hydrostatic pulmonary edema after coronary artery ligation in open-chest dogs?

Population

28 open-chest dogs divided into four groups: left anterior descending coronary artery ligation, sham…

Comparison

Indomethacin infusion begun prior to coronary… vs Sham coronary ligation, coronary ligation alone…

Design

Preclinical

Follow-up

2 hours after ligation

Authors

JRJ. Franklin RichesonAtrium Health Wake Forest BaptistCPC PaulshockPYPang Yun

Discussion

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Implication

Suggests cyclooxygenase inhibition may limit permeability edema post-MI in dogs; leaves open clinical translation.

Structured PICO

Does indomethacin infusion prevent non-hydrostatic pulmonary edema after coronary artery ligation in open-chest dogs?

P
Population
28 open-chest dogs divided into four groups: left anterior descending coronary artery ligation (n=9), sham coronary ligation (n=7), ligation after indomethacin infusion (n=7), and ligation after vehicle infusion (n=5).
I
Intervention
Indomethacin infusion (5 mg/kg per hr) begun prior to coronary artery ligation.
C
Comparator
Sham coronary ligation, coronary ligation alone, or coronary ligation after vehicle infusion.
O
Outcome
Pulmonary extravascular water volume and gravimetric lung water.surrogate

Indomethacin prevents the formation of non-hydrostatic pulmonary edema following acute myocardial infarction in a canine model, suggesting that increased microvascular permeability, possibly mediated by cyclo-oxygenase products, contributes to edema formation.

Cite This Study

Richeson et al. (1982) studied this question.

synapsesocial.com/papers/6a7e3c301fdb7ee677c768a0https://doi.org/10.1161/01.res.50.2.301
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Extravascular water content of heart and lungs after acute myocardial ischemia1978 · 29 citations
  2. 2Increased lung lymph transport without heart failure after coronary ligation in sheep1979 · 16 citations
  3. 3Regional cardiac prostaglandin release during myocardial ischemia in anesthetized dogs.1976 · 114 citations
  4. 4Pulmonary oedema without critical increase in left atrial pressure in acute myocardial infarction.1981 · 32 citations
  5. 5Arachidonate raises vascular resistance but not permeability in lungs of awake sheep1980 · 45 citations