Why the study?
Does spontaneously developed coronary collateral circulation prevent ischemic injury (ST-segment elevation) after coronary ligation in dogs?
Population
121 dogs undergoing ligation of the anterior descending coronary artery
Comparison
Presence of spontaneously developed coronary… vs Absence of significant spontaneously developed…
Design
Preclinical
Authors
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Collateral flow mitigates acute ischemia in this canine model; leaves open translation to human coronary syndromes.
Does spontaneously developed coronary collateral circulation prevent ischemic injury (ST-segment elevation) after coronary ligation in dogs?
Spontaneously developed coronary collateral circulation significantly reduces epicardial ischemic injury following acute coronary ligation in a canine model.
Mizutani et al. (1979) studied this question.
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