Key result
Exercise-induced depression of left ventricular function in the ischemic heart correlated with the amount of coronary collateral flow, with significant cardiac failure developing in dogs with low collateral flow.
Why the study?
Does the amount of coronary collateral flow correlate with exercise-induced depression of left ventricular function during transient coronary occlusion in dogs?
Does the amount of coronary collateral flow correlate with exercise-induced depression of left ventricular function during transient coronary occlusion in dogs?
Exercise-induced depression of left ventricular function in the ischemic heart correlates inversely with the amount of coronary collateral flow in a canine model.
No takes yet. Share an insight, caveat, or question.
Supports collateral-dependent protection against ischemic LV dysfunction in dogs; leaves open relevance to human exercise testing in CAD.
Cohen et al. (1979) studied Prior constriction of the left circumflex coronary artery (n=14). 1-min left circumflex coronary artery occlusion vs. Before occlusion / at rest was evaluated on Hemodynamics and collateral flow. Exercise-induced depression of left ventricular function in the ischemic heart correlated with the amount of coronary collateral flow, with significant cardiac failure developing in dogs with low collateral flow.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: