What question did this study set out to answer?

To evaluate whether a chronic exercise-training regimen stimulates coronary collateral vessel development and preserves myocardial blood flow during coronary artery stenosis.

March 1, 1982Journal of Applied Physiology

Coronary collateral stimulation by exercise in dogs with stenotic coronary arteries

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Why the study?

Does exercise training improve coronary collateral development in dogs with stenotic coronary arteries?

Key Points

To evaluate whether a chronic exercise-training regimen stimulates coronary collateral vessel development and preserves myocardial blood flow during coronary artery stenosis.
Instrumented 13 one-year-old beagles with left circumflex (LCf) coronary artery flow probes, balloon occluders, and catheters, creating a 58 ± 4% reduction in peak reactive hyperemia.
Randomized animals to either cage confinement (sedentary, N=6) or a 12-week exercise regimen consisting of sprint and endurance treadmill running for 75 min/day, 5 days/week (N=7).
Assessed resting and exercise hemodynamics and measured myocardial blood flow using left-atrial radioactively labeled microspheres during LCf occlusion at baseline and after 12 weeks.
Trained dogs showed an increase in resting collateral blood flow from 0.52 ± 0.16 ml·min⁻¹·g⁻¹ at week 1 to 0.90 ± 0.28 ml·min⁻¹·g⁻¹ at week 12 (P < 0.05).
The ratio of collateral to normal myocardial blood flow increased from 0.46 ± 0.12 to 0.64 ± 0.16 (P < 0.05) in exercising dogs, with reduced evidence of left ventricular failure during exercise occlusion.
Sedentary control dogs showed no statistically significant alterations in hemodynamic indices or myocardial collateral blood flow over the 12-week study period.

Structured PICO

Does exercise training improve coronary collateral development in dogs with stenotic coronary arteries?

Population

13 1-yr-old beagles with left circumflex (LCf) coronary artery constriction (58 +/- 4% reduction of peak reactive hyperemia response)

Intervention

Exercise training (sprint and endurance running for 75 min/day, 5 days/wk) for 12 weeks

Comparator

Sedentary (confined to cages) for 12 weeks

Outcome

Coronary collateral development (myocardial blood flow and hemodynamics at rest and during treadmill running)surrogate

Chronic exercise training stimulates coronary collateral development and improves myocardial blood flow in a canine model of coronary stenosis.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May enhance collaterals in canine stenosis models; leaves open translation to human CAD.

Cite This Study

Cohen et al. (1982) studied this question.

synapsesocial.com/papers/6a1059992badbc352affd747 https://doi.org/10.1152/jappl.1982.52.3.664

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Coronary collateral stimulation by exercise in dogs with stenotic coronary arteries

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Coronary collateral stimulation by exercise in dogs with stenotic coronary arteries

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider